PROBAND (Closed to Recruitment)

This study is designed to improve our understanding of the mechanisms of Parkinson’s Disease, in particular to explore the variations in Parkinson’s Disease which are known to occur in the four following areas:

  1. Motor features – tremor, stiffness, slowness and poor balance
  2. The involvement of memory
  3. The degree of improvement with medication
  4. The presence of other symptoms including bowel, bladder and blood pressure control.

We think that there are gene variations that explain the different ways in which Parkinson’s affects the person with the disease. We know about some genes that are linked to Parkinson’s, but this is only in 5% of cases.

This study has now closed to recruitment. 


Findings so far: 

It was found that vascular comorbidity is significantly associated with cognitive and motor impairment in patients with early Parkinson's Disease; this may have prognostic and treatment implications. 

A recent study found support for the idea that there is a distinct clinical profile between two genes related to Parkinson's disease. 


Because this is a long term study, the PROBAND website gets regular updates as new findings come in. Please click here if you wish to go to the study website.

For more information please complete the following form: 

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